Fibromyalgia and Chronic Fatigue Syndrome

Fibromyalgia and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis / Chronic Fatigue Syndrome, ME/CFS) are complex, multi-system conditions that affect pain processing, energy regulation, sleep quality, cognitive function, and overall physiological resilience. Although they are distinct diagnoses, they frequently overlap and share features such as widespread musculoskeletal pain, persistent fatigue, heightened sensory sensitivity, and reduced tolerance to physical or cognitive stress. Current evidence suggests these conditions are not the result of structural injury alone, but rather reflect alterations in central pain processing, autonomic nervous system regulation, immune signaling, and stress physiology over time. Effective management therefore requires an individualized, paced approach that focuses on reducing physiological stress load, supporting nervous system regulation, and gradually restoring functional capacity in a safe and sustainable manner.

Common Causes and Triggers

These conditions rarely have a single cause. Common contributors and triggers may include:

  • Physical or emotional trauma

  • Chronic or acute infections (viral or bacterial)

  • Prolonged psychological stress or burnout

  • Sleep disruption or long-term sleep deprivation

  • Autonomic nervous system dysregulation

  • Hormonal or metabolic imbalances

  • Inflammatory or immune system stressors

  • Repeated overexertion without adequate recovery

Importantly, many patients can identify a “before and after” moment where symptoms began or escalated.

Typical Signs and Symptoms

Symptoms vary widely between individuals and may fluctuate day to day. Common features include:

  • Widespread muscle and joint pain

  • Persistent or overwhelming fatigue

  • Non-restorative sleep

  • Brain fog, poor concentration, or memory difficulties

  • Headaches or migraines

  • Dizziness or exercise intolerance

  • Heightened sensitivity to touch, light, noise, or temperature

  • Mood changes related to chronic pain and exhaustion

How the Condition Is Evaluated, Managed, and When to Seek Support

There is no single test that confirms fibromyalgia or Chronic Fatigue Syndrome (ME/CFS). Evaluation focuses on understanding the full picture, including symptom patterns over time, pain distribution, fatigue levels, sleep quality, stress tolerance, medical history, lifestyle factors, and prior injuries or illnesses. Part of the process also involves ruling out other medical or neurological conditions when appropriate, and identifying factors that consistently worsen or improve symptoms.

Management is individualized and paced. The goal is not to push through symptoms or force progress, but to reduce overall system overload, support nervous system regulation, and gradually build tolerance to daily activities without triggering flare-ups. Progress is often non-linear, with periods of improvement and setbacks, and this is a normal part of managing these conditions.

Support should be considered when pain, fatigue, brain fog, or poor sleep persist for months, worsen with physical or mental exertion, interfere with daily life, or lead to repeated cycles of flare-ups and crashes. Early guidance can help reduce further sensitization, prevent deconditioning, and provide strategies for pacing, recovery, and long-term symptom management.

Treatments Commonly Used at ONE80 Health

Care for fibromyalgia and Chronic Fatigue Syndrome focuses on calming an over-stressed system, reducing sensitivity, and improving tolerance to daily movement and activity. Depending on the individual, treatment may include:

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